Background of Human Thrombin

Product name: Human Thrombin
Description: Human Thrombin
Source: Human
Background : Thrombin is the final protease in the blood coagulation cascade and serves both pro- and anticoagulant functions through the cleavage of several targets. The ability of thrombin to specifically recognize a wide range of substrates derives from interactions which occur outside of the active site of thrombin. Thrombin possesses two anion binding exosites which mediate many of its interactions with cofactors and substrates, and although many structures of thrombin have been solved, few such interactions have been described in molecular detail. Glycosaminoglycan binding to exosite II of thrombin plays a major role in switching off the procoagulant functions of thrombin by mediating its irreversible inhibition by circulating serpins and by its binding to the endothelial cell surface receptor thrombomodulin.
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How to Use Human Hepatitis B Immunoglobulin

Product name: Human Hepatitis B Immunoglobulin
Description: The Hepatitis B Immunoglobulin is extracted and isolated by cold ethanol fractionation and virus inactivation from the highly efficient plasma of healthy persons immunized with hepatitis B virus vaccine. The liquid agent of Hepatitis B immunogobulin apparent with slight opalescence is almost colorless or pale yellow in colorless or pale yellow in color. More than 90% protein contained is immunoglobulin. The apparent efficacy of antibody of hepatitis B virus is not less than 100IU/ml. The preparation is indicated for the treatment of shock causes by bleeding, wound of bum, cerebral edema; Intracranial hypertension caused by brain trauma; Byplalbuminemia and edema or ascites caused by cirrhosis or rendl diseases
Main Application:
1. Cutting off hepatitis B (HBsAg) infection of infants from virus carried by mothers
2. Crowd infected unexpectedly
3. Individuals intimately contacted with hepatitis B patients or hepatitis B virus carriers.
4. Individuals of poor immunological functioning
5. Application after liver transplant
Injection Dosage: 400IU, 200IU, 100IU.

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Human Immunoglobulin (pH4) for Intravenous Injection

Product name: Human Immunoglobulin (pH4) for Intravenous Injection
Function:Immunomodulator Drugs

Indications: 
1.Primary immunodeficiency diseases such as X linked agammaglobulinemia, common variable immunodeficiency, immunoglobulin G subtype deficiency, etc.
2.Acquired immunodeficiencies, such as serious infection, sepsis in the newborns
3.Self immune diseases such as idiopathic thrombocytopenic purpura(ITP), Kawasaki syndrome 
Specification 5g(5% 100ml)2.5g(5% 50ml).25g(5% 25ml) .

Description: the present product has IgG antibody for broad spectrum anti-virus, bacteria and other causative agents. In addition, the typical and unique antibody of the immunoglobulin is able to constitute a complex immune network, thus having a dual function of immunity substitute and immnoregulation. After an intravenous infusion and injection, it can quickly raise IgG level in the blood of the person who receiving the infusion and injection, strengthening ability of human bodies to resist infection and immune regulation function.
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Human Coagulation Factor VIII Supplier

Product name: Human Coagulation Factor VIII
Application:ELISA, Inhibition Assays, Western Blotting

Presentation:100μl purified human factor VIII protein at 100μg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide

Description:
The human coagulation factor VIII is assayed by its biological activity as a cofactor in the activation of factor X by activated factor IX (factor IXa) in the presence of calcium ions and phospholipids. The assay consists of two consecutive steps: the factor VIII-dependent activation of factor X and the enzymatic cleavage of a chromogenic factor Xa substrate that can be quantified photometrically. Many commercial kits are available for this purpose
Factor VIII (FVIII) is an essential clotting factor in the coagulation cascade. The lack of normal FVIII causes Hemophilia A, an inherited bleeding disorder. FVIII harvested from donated blood/blood plasma or recombinant FVIII can be given to hemophiliacs to restore hemostasis. Thus, FVIII is also known as Anti-Hemophilic Factor

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What is Human Prothrombin Complex

Product name: Human Prothrombin Complex
Category Group: Cancer and Signaling Proteins
Synonyms: PCC, Prothrombin Complex

Product Description: Prothrombin complex is a double virus–inactivated concentrate, containing equal concentrations of Factors II, VIII, IX, X and Heparin. 
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder
Formulation Lyophilized Powder from 0.1M sodium chloride and 10mM sodium citrate buffer
Storage / Stability: Lyophilized Prothrombin-Complex although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Prothrombin-Complex should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. 

Backgound:Prothrombin Complex Concentrate (PCC) is a combination of several blood clotting factors II, VII, IX and X. PCC is used in the treatment of the congenital bleeding disorders associated with Factors II, VII, IX, and X deficiencies. PCC reverses the effect of warfarin (a coumarin anti-coagulant) and is used in cases of significant bleeding in patients with a coagulopathy, for example, gastrointestinal haemorrhage or intracranial haemorrhage. The PCC is also extensively used in treating acquired coagulation abnormalities secondary to vitamin K deficiency, warfarin ingestion, and various types of liver disease. Hepatitis, anaphylaxis and thrombosis have been reported as complications of prothrombin complex concentrates administration.
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What is Human Thrombin ?

Product name:Human Thrombin

Description:This immunoassay kit allows for the in vitro quantitative determination of human TM concentrations in serum, plasma and other biological fluids.Thrombin is an enzyme resulting from activation of prothrombin, which catalyzes the conversion of fibrinogen to fibrin. It is also a potent stimulus to the aggregation of platelets.

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Where to buy Surgical Lyophilized Fibrin Sealant, Human?

Product name:Surgical Lyophilized Fibrin Sealant, Human

Description:
Fibrin sealant can also be justified as an alternative to factor concentrates in patients with coagulopathies who have a localized site of bleeding. Newer formulations of fibrinogen and thrombin in a freeze-dried form applied as a bandage may be useful in immediate, on-site treatment of trauma victims in either a civilian or military setting.

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